New Antibiotics from Microbial Metabolomic "Dark Matter". Complementing our work on nematodes, we apply 2D NMR-based comparative metabolomics as a new strategy to identify the small-molecule products of cryptic PKS and NRPS gene clusters in bacteria and fungi, focusing in particular on the identification of virulence factors and antimicrobial compounds. BSMs of microbial origin represent the most important source for new drug leads, especially for the treatment of infectious disease and cancer. Recent technical advances that further accelerate detection and characterization of new structural entities include the development of algorithms for the partially automated comparative analysis of high-resolution 2D NMR spectra and the use of heterologous expression of gene clusters in A. nidulans.
The 21st century will be the age of biology, extending a century-long revolution in the biological sciences, with the future quality of human existence being strongly dependent on future advances in the life sciences. Key historic developments in agriculture, medicine, and technology have reduced human mortality rates, causing a human population explosion. This, in turn, has driven accelerating demands for basic and applied biological knowledge, particularly in cellular-molecular-and-developmental-biology with implications for medicine, agriculture, genetic engineering, and forensic science; and in evolution-and-ecology with implications for the conservation of natural resources and restoration of ecosystems severely disturbed by human activities.
Latina/o Studies is dedicated to the study of the historical, linguistic, literary, social, economic, and political experiences of a vastly heterogeneous population in the United States, that today totals over 55 million people. Officially founded in 1987 as the Hispanic American Studies Program, our name was changed to the Latina/o Studies Program in 1995. We nurture familia, inquire into the important questions of the day, and through our courses and other intellectual activities—conferences, lectures, exhibits, dialogues, and other research initiatives and activities--learn how Latinas/os contribute to a greater understanding of the world, through the analysis of politics, migration histories, health, labor insertion, literature, and the arts.